BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Stanford School of Medicine at Stanford Research Park - ECPv6.16.5//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://srp.med.stanford.edu
X-WR-CALDESC:Events for Stanford School of Medicine at Stanford Research Park
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Los_Angeles
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20250309T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20251102T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20260308T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20261101T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20270314T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20271107T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260514T120000
DTEND;TZID=America/Los_Angeles:20260514T130000
DTSTAMP:20260514T181924Z
CREATED:20260514T181924Z
LAST-MODIFIED:20260514T181924Z
UID:4100-1778760000-1778763600@srp.med.stanford.edu
SUMMARY:Wu Tsai Neuro Seminar w/ X. William Yang - SRP Livestream Locations
DESCRIPTION:Good morning SOM Stanford Research Park Community\, \nWe invite you to join us for today’s Neurosciences Seminar. The seminar will be held in-person on the main Stanford campus with 3 satellite viewing locations in Stanford Research Park. \n🗓️ May 14\, 2026\nBeyond the inherited CAG: Decoding a neuronal-selective pathogenic cascade in Huntington’s disease\nX. William Yang\, MD\, PhD\nUniversity of California\, Los Angeles | Host: Andy Tsai (Wyss-Coray Lab) \nHuntington’s disease (HD) is caused by a CAG repeat expansion in the huntingtin gene\, and disease onset as well as clinical progression are modified by multiple GWAS loci enriched for DNA repair genes\, including multiple mismatch repair (MMR) genes and FAN1. Here\, I will present a series of studies—primarily using mouse genetic models of HD—to illustrate key pathogenic steps that lead to selective pathogenesis of the striatal medium spiny neurons (MSNs)\, the most vulnerable neuronal cell types in HD. Our studies show that a subset of HD GWAS/MMR genes (i.e..\, Msh3 and Pms1) are key drivers of somatic CAG repeat expansion in the endogenous murine mutant huntingtin (mHtt)\, with MSNs showing the fastest rates of expansion. Consequently\, these mice display somatic repeat length– and threshold-dependent\, molecular and pathological phenotypes. Downstream of somatic repeat expansion\, polyglutamine (polyQ)-expanded mHtt species accumulate in the nuclei of affected neurons\, where they elicit proteotoxicity leading to profound chromatin defects. The latter include erosion of epigenomic signatures of MSN identity. Together\, our studies reveal distinct pathogenic steps in HD pathogenesis and provide new insights and model platforms to develop therapies. \n⏰ Time: 12:00-1:00 PM (PT)\nCome 15 minutes early (11:45 AM) to enjoy coffee\, cookies\, and conversation with the speaker and your colleagues (main campus location only) \n📍 Locations: \n\nMain Campus (in person): Gunn Rotunda (E241)\, Stanford Neurosciences Building\nStanford Research Park satellite locations:\n\n3172 Porter Drive\, Room 253\n3174 Porter Drive\, Room 140\n1070 Arastradero Road\, Room 211\n\n\n\nLearn about the SRP satellites » \nLearn more and get involved:\n\nNominate speakers for the 2026-2027 seminar series\nAbout the Wu Tsai Neurosciences Seminar Series »\nSign up to dine or meet with the seminar speakers »\nSee all upcoming and past seminars »\nSign up for Wu Tsai Neuro’s mailing list »\nJoin the #neuroscience slack channel »\n\n📅 Want to add all of the seminars to your calendar?\nDownload the calendar here or\, for live updates\, copy this link and use these instructions for subscribing to a public calendar: Outlook\, Mac\, Google Calendar. \nBest regards\,\nEmily Elrod (she/they)
URL:https://srp.med.stanford.edu/event/wu-tsai-neuro-seminar-w-x-william-yang-srp-livestream-locations/
LOCATION:Stanford Neurosciences Building\, 290 Jane Stanford Way\, Stanford\, CA\, 94305\, United States
CATEGORIES:In Person
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260514T140000
DTEND;TZID=America/Los_Angeles:20260514T150000
DTSTAMP:20260508T154633Z
CREATED:20260508T154153Z
LAST-MODIFIED:20260508T154633Z
UID:4072-1778767200-1778770800@srp.med.stanford.edu
SUMMARY:VWR Coffee Hour
DESCRIPTION:Join us for a VWR Coffee Hour \n3165 Porter Dr\, RM 253\nThursday\, May 14\n2PM – 3PM \nYou’re warmly invited to a coffee hour hosted by VWR. Come meet your support team over coffee\, treats\, and some lab supply fun! \nContact your VWR Sales Representative:\nAndrew Vargas\nVWR Sales Representative\nM: 408.444.3891\nAndrew.Vargas@avantorsciences.com
URL:https://srp.med.stanford.edu/event/vwr-coffee-hour-3/
LOCATION:Híišen Hall (3165 Porter Drive)
CATEGORIES:In Person
ATTACH;FMTTYPE=image/png:https://srp.med.stanford.edu/wp-content/uploads/2026/05/vwr-may-14.png
END:VEVENT
END:VCALENDAR